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Exploring models of the influenza A M2 channel: MD simulations in a phospholipid bilayer.

Abstract:

The M2 protein of influenza A virus forms homotetrameric helix bundles, which function as proton-selective channels. The native form of the protein is 97 residues long, although peptides representing the transmembrane section display ion channel activity, which (like the native channel) is blocked by the antiviral drug amantadine. As a small ion channel, M2 may provide useful insights into more complex channel systems. Models of tetrameric bundles of helices containing either 18 or 22 residue...

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Publication status:
Published

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Journal:
Biophysical journal More from this journal
Volume:
78
Issue:
1
Pages:
55-69
Publication date:
2000-01-01
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Language:
English
Keywords:
Pubs id:
pubs:100774
UUID:
uuid:aa5a087b-9049-49d0-b777-4ad435cfc5db
Local pid:
pubs:100774
Source identifiers:
100774
Deposit date:
2012-12-19

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