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Thesis

Imputation aided analysis of the association between autoimmune diseases and the MHC

Abstract:

The Major Histocompatibility Complex (MHC) is a genomic region in chromosome 6 which has been consistently found to be associated with the risk of developing virtually all common autoimmune diseases. Although its importance in disease pathogenesis has been known for decades, efforts to disentangle the roles of the classical human leukocyte antigens (HLA) and other variants responsible for the susceptibility to disease have often met with limited success, owing to the complex structure and ...

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Institution:
University of Oxford
Research group:
Statistical Genetics & Bioinformatics
Oxford college:
Hertford College
Department:
Mathematical,Physical & Life Sciences Division - Statistics

Contributors

Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:aa570447-9e25-42de-b10d-9f445c0a094e
Local pid:
ora:5929

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