Journal article icon

Journal article

Maturation of the human immunoglobulin heavy chain repertoire with age

Abstract:

B cells play a central role in adaptive immune processes, mainly through the production of antibodies. The maturation of the B cell system with age is poorly studied. We extensively investigated age-related alterations of naïve and antigen-experienced immunoglobulin heavy chain (IgH) repertoires. The most significant changes were observed in the first 10 years of life, and were characterized by altered immunoglobulin gene usage and an increased frequency of mutated antibodies structurally div...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More from this funder
Name:
Swiss National Science Foundation
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
11
Article number:
1734
Place of publication:
Switzerland
Publication date:
2020-08-06
Acceptance date:
2020-06-29
DOI:
EISSN:
1664-3224
Pmid:
32849618
Language:
English
Keywords:
Pubs id:
1128203
Local pid:
pubs:1128203
Deposit date:
2021-03-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP