Journal article
Maturation of the human immunoglobulin heavy chain repertoire with age
- Abstract:
- B cells play a central role in adaptive immune processes, mainly through the production of antibodies. The maturation of the B cell system with age is poorly studied. We extensively investigated age-related alterations of naïve and antigen-experienced immunoglobulin heavy chain (IgH) repertoires. The most significant changes were observed in the first 10 years of life, and were characterized by altered immunoglobulin gene usage and an increased frequency of mutated antibodies structurally diverging from their germline precursors. Older age was associated with an increased usage of downstream IgH constant region genes and fewer antibodies with self-reactive properties. As mutations accumulated with age, the frequency of germline-encoded self-reactive antibodies decreased, indicating a possible beneficial role of self-reactive B cells in the developing immune system. Our results suggest a continuous process of change through childhood across a broad range of parameters characterizing IgH repertoires and stress the importance of using well-selected, age-appropriate controls in IgH studies.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.9MB, Terms of use)
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- Publisher copy:
- 10.3389/fimmu.2020.01734
Authors
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Immunology More from this journal
- Volume:
- 11
- Article number:
- 1734
- Place of publication:
- Switzerland
- Publication date:
- 2020-08-06
- Acceptance date:
- 2020-06-29
- DOI:
- EISSN:
-
1664-3224
- Pmid:
-
32849618
- Language:
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English
- Keywords:
- Pubs id:
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1128203
- Local pid:
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pubs:1128203
- Deposit date:
-
2021-03-16
- ARK identifier:
Terms of use
- Copyright holder:
- M Graichy et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 Ghraichy, Galson, Kovaltsuk, von Niederhäusern, Pachlopnik Schmid, Recher, Jauch, Miho, Kelly, Deane and Trück. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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