Journal article
Development and application of ligand-based NMR screening assays for γ-butyrobetaine hydroxylase
- Abstract:
-
γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate (2OG) dependent oxygenase that catalyses the stereoselective C-3 hydroxylation of γ-butyrobetaine (GBB) to give L-carnitine. L-carnitine is involved in fatty acid metabolism in all animals and in some prokaryotes, and BBOX is a current drug target for the treatment of myocardial infarction. We describe the development and application of 1 H NMR GBB/2OG reporter based assays employing paramagnetic relaxation enhancement to monitor inhibito...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Wellcome Trust
More from this funder
Cancer Research UK
More from this funder
British Heart Foundation
More from this funder
Biotechnology and Biological Sciences Research Council
More from this funder
Bibliographic Details
- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- MedChemComm Journal website
- Publication date:
- 2016-02-17
- Acceptance date:
- 2016-02-15
- DOI:
- EISSN:
-
2040-2511
- ISSN:
-
2040-2503
Item Description
- Pubs id:
-
pubs:604478
- UUID:
-
uuid:aa427c2c-74cf-4d55-9d44-acd76a526391
- Local pid:
- pubs:604478
- Source identifiers:
-
604478
- Deposit date:
- 2016-02-16
Terms of use
- Copyright holder:
- Royal Society of Chemistry
- Copyright date:
- 2016
- Notes:
- This journal is © The Royal Society of Chemistry 2016. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.. The final version is available online from The Royal Society of Chemistry at: [10.1039/c6md00004e]
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record