Presence and pathogenic relevance of antibodies to clustered acetylcholine receptor in ocular and generalized myasthenia gravis.

Journal article

BACKGROUND: Clustered acetylcholine receptor antibodies (clustered AChR-Abs) have been detected in a proportion of patients with previously "seronegative" (SN) generalized myasthenia gravis (GMG), but their presence in patients with ocular MG (OMG) and their pathogenicity in vivo are unknown. OBJECTIVE: To test the presence of clustered AChR-Abs and their pathophysiologic properties in patients with SNMG. DESIGN: Screening and diagnostic tests. SETTING: Regional specialist myasthenia center ...

Expand abstract

Authors: Jacob, S; Viegas, S; Leite, M; Webster, R; Cossins, J

• Publication status: Published
• Journal: Archives of neurology
• Volume: 69
• Issue: 8
• Pages: 994-1001
• Publication date: 2012-08-01
• DOI: 10.1001/archneurol.2012.437
• EISSN: 1538-3687
• ISSN: 0003-9942
• Language: English
• Keywords: Ocular Motility Disorders; Receptors, Cholinergic; Mice, Inbred C57BL; Female; HEK293 Cells; Mice, Knockout; Middle Aged; Animals; Male; Mice; Humans; Protein Binding; Myasthenia Gravis; Adult; Autoantibodies