Journal article
Synthesis of novel pyridine-carboxylates as small-molecule inhibitors of human aspartate/asparagine-β-hydroxylase
- Abstract:
-
The human 2-oxoglutarate (2OG)-dependent oxygenase aspartate/asparagine-β-hydroxylase (AspH) is a potential medicinal chemistry target for anti-cancer therapy. AspH is overexpressed on the cell surface of invasive cancer cells and accepts epidermal growth factor-like domain (EGFDs) substrates with a non-canonical ( i.e. Cys 1-2, 3-4, 5-6) disulfide pattern. We report a concise synthesis of C-3 substituted derivatives of pyridine-2,4-dicarboxylic acid (2,4-PDCA) as 2OG competitors for us...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Funding
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- ChemMedChem Journal website
- Volume:
- 15
- Issue:
- 2020
- Pages:
- 1139 –1149
- Publication date:
- 2020-04-24
- Acceptance date:
- 2020-04-21
- DOI:
- EISSN:
-
1860-7187
- ISSN:
-
1860-7179
- Pmid:
-
32330361
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1101871
- Local pid:
- pubs:1101871
- Deposit date:
- 2020-05-20
Terms of use
- Copyright holder:
- Wiley
- Copyright date:
- 2020
- Rights statement:
- © 2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This article is open access via creative commons licensing.
- Licence:
- CC Attribution (CC BY)
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