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Imaging intracellular viscosity of a single cell during photoinduced cell death.

Abstract:

Diffusion-mediated cellular processes, such as metabolism, signalling and transport, depend on the hydrodynamic properties of the intracellular matrix. Photodynamic therapy, used in the treatment of cancer, relies on the generation of short-lived cytotoxic agents within a cell on irradiation of a drug. The efficacy of this treatment depends on the viscosity of the medium through which the cytotoxic agent must diffuse. Here, spectrally resolved fluorescence measurements of a porphyrin-dimer-ba...

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Publication status:
Published

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Publisher copy:
10.1038/nchem.120

Authors


Kuimova, MK More by this author
Botchway, SW More by this author
Parker, AW More by this author
Collins, HA More by this author
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Journal:
Nature chemistry
Volume:
1
Issue:
1
Pages:
69-73
Publication date:
2009-04-05
DOI:
EISSN:
1755-4349
ISSN:
1755-4330
URN:
uuid:a9e57fd1-f5ee-4741-8981-4c8feeb0b141
Source identifiers:
51861
Local pid:
pubs:51861

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