Journal article
Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel
- Abstract:
-
Two-pore domain (K2P) K+ channels have many important physiological functions. However, the functional properties of the TWIK-1 (K2P1.1/KCNK1) K2P channel remain poorly characterized because heterologous expression of this ion channel yields only very low levels of functional activity. Several underlying reasons have been proposed, including TWIK-1 retention in intracellular organelles, inhibition by post-translational sumoylation, a hydrophobic barrier within the pore, and a low open probabi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Journal of Biological Chemistry Journal website
- Volume:
- 295
- Issue:
- 2
- Pages:
- 610–618
- Publication date:
- 2019-12-05
- Acceptance date:
- 2019-12-04
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Pmid:
-
31806709
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1077225
- UUID:
-
uuid:a9dfcbe5-5d4b-4ef6-8a3c-50435345ac25
- Local pid:
- pubs:1077225
- Source identifiers:
-
1077225
- Deposit date:
- 2019-12-27
Terms of use
- Copyright holder:
- Nematian-Ardestani, E et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 Nematian-Ardestani et al. Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.
- Notes:
- This is the publisher's version of the article. The final version is available online from the American Society for Biochemistry and Molecular Biology at: https://doi.org/10.1074/jbc.RA119.010612
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