Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells.

Journal article

To gain insight into the molecular pathogenesis of the myelodysplastic syndromes (MDS), we performed global gene expression profiling and pathway analysis on the hematopoietic stem cells (HSC) of 183 MDS patients as compared with the HSC of 17 healthy controls. The most significantly deregulated pathways in MDS include interferon signaling, thrombopoietin signaling and the Wnt pathways. Among the most significantly deregulated gene pathways in early MDS are immunodeficiency, apoptosis and che...

Expand abstract

Authors: Pellagatti, A; Cazzola, M; Giagounidis, A; Perry, J; Malcovati, L

• Publication status: Published
• Journal: Leukemia
• Volume: 24
• Issue: 4
• Pages: 756-764
• Publication date: 2010-04-01
• DOI: 10.1038/leu.2010.31
• EISSN: 1476-5551
• ISSN: 0887-6924
• Language: English
• Keywords: Case-Control Studies; RNA, Messenger; Hematopoietic Stem Cells; Humans; Chromosome Deletion; Tumor Markers, Biological; Reverse Transcriptase Polymerase Chain Reaction; Gene Expression Profiling; Trisomy; Chromosomes, Human, Pair 8; Oligonucleotide Array Sequence Analysis; Signal Transduction; Myelodysplastic Syndromes; Gene Expression Regulation, Neoplastic; Chromosomes, Human, Pair 5; Chromosomes, Human, Pair 7