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Journal article : Review

From polymer chemistry to structural biology: The development of SMA and related amphipathic polymers for membrane protein extraction and solubilisation

Abstract:

Nanoparticles assembled with poly(styrene-maleic acid) copolymers, identified in the literature as Lipodisq, SMALPs or Native Nanodisc, are routinely used as membrane mimetics to stabilise protein structures in their native conformation. To date, transmembrane proteins of varying complexity (up to 8 beta strands or 48 alpha helices) and of a range of molecular weights (from 27 kDa up to 500 kDa) have been incorporated into this particle system for structural and functional studi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.chemphyslip.2019.03.008

Authors


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Role:
Author
ORCID:
0000-0002-1337-6424
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
St Hugh's College
Role:
Author
ORCID:
0000-0003-4976-1102
Publisher:
Elsevier
Journal:
Chemistry and Physics of Lipids More from this journal
Volume:
221
Pages:
167-175
Publication date:
2019-03-30
Acceptance date:
2019-03-15
DOI:
EISSN:
1873-2941
ISSN:
0009-3084
Pmid:
30940445
Language:
English
Keywords:
Subtype:
Review
Pubs id:
991343
Local pid:
pubs:991343
Deposit date:
2020-06-10

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