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Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging.

Abstract:

The original concept of the ischaemic penumbra suggested imaging of regional cerebral blood flow and metabolism would be required to identify tissue that may benefit from intervention. Amide proton transfer magnetic resonance imaging, a chemical exchange saturation transfer technique, has been used to derive cerebral intracellular pH in preclinical stroke models and has been proposed as a metabolic marker of ischaemic penumbra. In this proof of principle clinical study, we explored the potent...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More from this funder
Name:
Engineering and Physical Sciences Research Council
Grant:
WT088877/Z/09/Z
More from this funder
Name:
Wellcome Trust
Grant:
WT088877/Z/09/Z
More from this funder
Name:
Dunhill Medical Trust
Grant:
OSRP1/1006
More from this funder
Name:
National Institute for Health Research
Publisher:
Oxford University Press
Journal:
Brain More from this journal
Volume:
138
Issue:
Pt 1
Pages:
36-42
Publication date:
2015-10-01
Acceptance date:
2014-10-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Language:
English
Keywords:
Pubs id:
pubs:503143
UUID:
uuid:a979af71-014a-4b83-8e3a-754885497ac4
Local pid:
pubs:503143
Source identifiers:
503143
Deposit date:
2015-01-16

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