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Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging.

Abstract:

The original concept of the ischaemic penumbra suggested imaging of regional cerebral blood flow and metabolism would be required to identify tissue that may benefit from intervention. Amide proton transfer magnetic resonance imaging, a chemical exchange saturation transfer technique, has been used to derive cerebral intracellular pH in preclinical stroke models and has been proposed as a metabolic marker of ischaemic penumbra. In this proof of principle clinical study, we explored the potent...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/brain/awu374

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Thandeswaran, S More by this author
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National Institute for Health Research More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
138
Issue:
Pt 1
Pages:
36-42
Publication date:
2015-10-05
Acceptance date:
2014-10-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:a979af71-014a-4b83-8e3a-754885497ac4
Source identifiers:
503143
Local pid:
pubs:503143

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