Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance.

Journal article

Allogeneic reactions are the major limitation to organ transplantation. These are manifested as rejection of the grafted tissue, and also, in the case of bone marrow transplantation (BMT), graft-versus-host disease (GVHD). Recent methods of avoiding GVHD, by depleting T cells from donor marrow, have led to an increased incidence of marrow graft rejection. Current recipient conditioning protocols involving drugs or irradiation cannot safely be increased, so alternatives must be found. Monoclon...

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Authors: Cobbold, S; Martin, G; Qin, S; Waldmann, H

• Publication status: Published
• Journal: Nature
• Volume: 323
• Issue: 6084
• Pages: 164-166
• Publication date: 1986-01-01
• DOI: 10.1038/323164a0
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Chimera; Mice, Inbred CBA; Skin Transplantation; Antibodies, Monoclonal; Graft vs Host Disease; Graft Survival; Mice; Bone Marrow Transplantation; Animals; Lymphocyte Depletion; T-Lymphocytes