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Journal article

Link between the numbers of particles and variants founding new HIV-1 infections depends on the timing of transmission

Abstract:

Understanding which HIV-1 variants are most likely to be transmitted is important for vaccine design and predicting virus evolution. Since most infections are founded by single variants, it has been suggested that selection at transmission has a key role in governing which variants are transmitted. We show that the composition of the viral population within the donor at the time of transmission is also important. To support this argument, we developed a probabilistic model describing HIV-1 tr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/ve/vey038

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Oxford college:
Christ Church
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Big Data Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Big Data Institute
Role:
Author
More from this funder
Name:
European Research Council
Funding agency for:
Wymant, C
Fraser, C
Grant:
PBDR-339251
PBDR-339251
More from this funder
Name:
Christ Church
Funding agency for:
Thompson, R
Grant:
107652/Z15/Z
More from this funder
Name:
Wellcome Trust and Royal Society
Funding agency for:
Thompson, R
Raghwani, J
Lythgoe, K
Grant:
107652/Z15/Z
107652/Z15/Z
107652/Z15/Z
Publisher:
Oxford University Press
Journal:
Virus Evolution More from this journal
Volume:
5
Issue:
1
Publication date:
2019-01-30
Acceptance date:
2018-11-27
DOI:
EISSN:
2057-1577
Pubs id:
pubs:946604
UUID:
uuid:a963117f-b417-4ff4-a261-e2741794c55c
Local pid:
pubs:946604
Deposit date:
2018-11-27

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