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Journal article

Steric effects induce geometric remodeling of actin bundles in filopodia

Abstract:

Filopodia are ubiquitous fingerlike protrusions, spawned by many eukaryotic cells, to probe and interact with their environments. Polymerization dynamics of actin filaments, comprising the structural core of filopodia, largely determine their instantaneous lengths and overall lifetimes. The polymerization reactions at the filopodial tip require transport of G-actin, which enter the filopodial tube from the filopodial base and diffuse toward the filament barbed ends near the tip. Actin filamen...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bpj.2016.03.013

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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
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Funding agency for:
Erban, R
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Funding agency for:
Erban, R
Publisher:
Cell Press Publisher's website
Journal:
Biophysical Journal Journal website
Volume:
110
Issue:
9
Pages:
2066–2075
Publication date:
2016-01-01
Acceptance date:
2016-03-09
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Source identifiers:
615194
Pubs id:
pubs:615194
UUID:
uuid:a9556c4c-7c9d-469c-9111-bab220f9fccf
Local pid:
pubs:615194
Deposit date:
2016-04-14

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