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Journal article

Common variants at 6q22 and 17q21 are associated with intracranial volume.

Abstract:

During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 × 10(-8)) for brain volume. In contrast, intracranial volume was sig...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2245

Authors


Fornage, M More by this author
Seshadri, S More by this author
Schmidt, R More by this author
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Journal:
Nature genetics
Volume:
44
Issue:
5
Pages:
539-544
Publication date:
2012-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:a951307e-15c2-4766-abf7-b0459d6a979a
Source identifiers:
325293
Local pid:
pubs:325293

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