- Abstract:
-
Pancreatic beta-cells secrete insulin by Ca(2+)-dependent exocytosis of secretory granules. beta-cell exocytosis involves SNARE (soluble NSF-attachment protein receptor) proteins similar to those controlling neurotransmitter release and depends on the close association of L-type Ca(2+) channels and granules. In most cases, the secretory granules fuse individually but there is ultrastructural and biophysical evidence of multivesicular exocytosis. Estimates of the secretory rate in beta-cells i...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1113/jphysiol.2008.155317
-
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- Journal:
- The Journal of physiology
- Volume:
- 586
- Issue:
- 14
- Pages:
- 3313-3324
- Publication date:
- 2008-07-05
- DOI:
- EISSN:
-
1469-7793
- ISSN:
-
0022-3751
- URN:
-
uuid:a9391be8-c035-44ae-aa1c-198a75c1e5e9
- Source identifiers:
-
22620
- Local pid:
- pubs:22620
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Novel aspects of the molecular mechanisms controlling insulin secretion.
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