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Journal article

Novel aspects of the molecular mechanisms controlling insulin secretion.

Abstract:

Pancreatic beta-cells secrete insulin by Ca(2+)-dependent exocytosis of secretory granules. beta-cell exocytosis involves SNARE (soluble NSF-attachment protein receptor) proteins similar to those controlling neurotransmitter release and depends on the close association of L-type Ca(2+) channels and granules. In most cases, the secretory granules fuse individually but there is ultrastructural and biophysical evidence of multivesicular exocytosis. Estimates of the secretory rate in beta-cells i...

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Publication status:
Published

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Journal:
The Journal of physiology
Volume:
586
Issue:
14
Pages:
3313-3324
Publication date:
2008-07-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:a9391be8-c035-44ae-aa1c-198a75c1e5e9
Source identifiers:
22620
Local pid:
pubs:22620

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