Thesis
Dietary fibre manipulation as a potential endogenous mechanism of radiosensitisation in bladder cancer
- Abstract:
-
New non-toxic radiosensitisers are needed in the treatment of muscle-invasive bladder cancer because elderly patients are very vulnerable to chemotherapy-related toxicity of currently available radiosensitisers. Our previous study showed that high fibre diets sensitised RT112 xenografts to irradiation by modifying the gut microbiota and this phenotype was positively correlated with Bacteroides acidifaciens (BA) abundance. As the gut microbiota can enhance anti-tumoural immune responses, I ...
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Authors
Contributors
+ Kiltie, A
- Role:
- Supervisor
+ Vallis, K
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Oncology
- Role:
- Supervisor
- ORCID:
- 0000-0003-4672-5683
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Deposit date:
-
2022-10-28
Terms of use
- Copyright holder:
- Then, CK
- Copyright date:
- 2022
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