Journal article
R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling
- Abstract:
-
R-spondins (RSPOs) amplify WNT signaling during development and regenerative responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin signaling in cells lacking leucine-rich repeat-containing G-protein coupled receptors (LGRs) 4, 5 and 6 (Lebensohn and Rohatgi, 2018). We now show that heparan sulfate proteoglycans (HSPGs) act as alternative co-receptors for RSPO3 using a combination of ligand mutagenesis and ligand engineering. Mutations in RSPO3 residues predicted to...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
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Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Volume:
- 9
- Publication date:
- 2020-05-20
- Acceptance date:
- 2020-04-25
- DOI:
- EISSN:
-
2050-084X
- Pmid:
-
32432544
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1106679
- Local pid:
- pubs:1106679
- Deposit date:
- 2020-06-12
Terms of use
- Copyright holder:
- free of all copyright
- Copyright date:
- 2020
- Rights statement:
- This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
- Licence:
- CC Public Domain Dedication (CC0)
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