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Catalytic asymmetric synthesis of cyclohexanes by hydrogen borrowing annulations

Abstract:

Hydrogen borrowing catalysis serves as a powerful alternative to enolate alkylation, enabling the direct coupling of ketones with unactivated alcohols. However, to date, methods that enable control over the absolute stereochemical outcome of such a process have remained elusive. Here we report a catalytic asymmetric method for the synthesis of enantioenriched cyclohexanes from 1,5‐diols via hydrogen borrowing catalysis. This reaction is mediated by the addition of a chiral iridium(I) comple...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/anie.201907514

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More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Magdalen College
Role:
Author
Publisher:
Wiley Publisher's website
Journal:
Angewandte Chemie International Edition Journal website
Publication date:
2019-07-02
Acceptance date:
2019-07-02
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Keywords:
Pubs id:
pubs:1025692
UUID:
uuid:a900c746-6e47-4a62-b417-bd96dccfb73b
Local pid:
pubs:1025692
Source identifiers:
1025692
Deposit date:
2019-07-02

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