Journal article : Review
Metabolic checkpoints in rheumatoid arthritis
- Abstract:
- Several studies have highlighted the interplay between metabolism, immunity and inflammation. Both tissue resident and infiltrating immune cells play a major role in the inflammatory process of rheumatoid arthritis (RA) via the production of cytokines, adipocytokines and metabolic intermediates. These functions are metabolically demanding and require the most efficient use of bioenergetic pathways. The synovial membrane is the primary site of inflammation in RA and exhibits distinctive histological patterns characterized by different metabolism, prognosis and response to treatment. In the RA synovium, the high energy demand by stromal and infiltrating immune cells, causes the accumulation of metabolites, and adipo-cytokines, which carry out signaling functions, as well as activating transcription factors which act as metabolic sensors. These events drive immune and joint-resident cells to acquire pro-inflammatory effector functions which in turn perpetuate chronic inflammation. Whether metabolic changes are a consequence of the disease or one of the causes of RA pathogenesis is still under investigation. This review covers our current knowledge of cell metabolism in RA. Understanding the intricate interactions between metabolic pathways and the inflammatory and immune responses will provide more awareness of the mechanisms underlying RA pathogenesis and will identify novel therapeutic options to treat this disease.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 556.9KB, Terms of use)
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- Publisher copy:
- 10.3389/fphys.2020.00347
Authors
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Physiology More from this journal
- Volume:
- 11
- Article number:
- 347
- Publication date:
- 2020-04-17
- Acceptance date:
- 2020-03-26
- DOI:
- EISSN:
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1664-042X
- Pmid:
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32362840
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1103757
- Local pid:
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pubs:1103757
- Deposit date:
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2020-06-15
Terms of use
- Copyright holder:
- Pucino, Certo, Varricchi, Marone, Ursini, Rossi, De Paulis, Mauro, Raza and Buckley
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2020 Pucino, Certo, Varricchi, Marone, Ursini, Rossi, De Paulis, Mauro, Raza and Buckley. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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