Journal article
The global meningitis genome partnership
- Abstract:
- Genomic surveillance of bacterial meningitis pathogens is essential for effective disease control globally, enabling identification of emerging and expanding strains and consequent public health interventions. While there has been a rise in the use of whole genome sequencing, this has been driven predominately by a subset of countries with adequate capacity and resources. Global capacity to participate in surveillance needs to be expanded, particularly in low and middle-income countries with high disease burdens. In light of this, the WHO-led collaboration, Defeating Meningitis by 2030 Global Roadmap, has called for the establishment of a Global Meningitis Genome Partnership that links resources for: N. meningitidis (Nm), S. pneumoniae (Sp), H. influenzae (Hi) and S. agalactiae (Sa) to improve worldwide co-ordination of strain identification and tracking. Existing platforms containing relevant genomes include: PubMLST: Nm (31,622), Sp (15,132), Hi (1935), Sa (9026); The Wellcome Sanger Institute: Nm (13,711), Sp (> 24,000), Sa (6200), Hi (1738); and BMGAP: Nm (8785), Hi (2030). A steering group is being established to coordinate the initiative and encourage high-quality data curation. Next steps include: developing guidelines on open-access sharing of genomic data; defining a core set of metadata; and facilitating development of user-friendly interfaces that represent publicly available data.
- Publication status:
- In press
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 2.0MB, Terms of use)
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- Publisher copy:
- 10.1016/j.jinf.2020.06.064
Authors
- Publisher:
- Elsevier
- Journal:
- Journal of Infection More from this journal
- Volume:
- 81
- Issue:
- 4
- Pages:
- 510-520
- Publication date:
- 2020-06-29
- Acceptance date:
- 2020-06-26
- DOI:
- EISSN:
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1532-2742
- ISSN:
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0163-4453
- Pmid:
-
32615197
- Language:
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English
- Keywords:
- Pubs id:
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1116372
- Local pid:
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pubs:1116372
- Deposit date:
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2020-07-21
Terms of use
- Copyright holder:
- Rodgers et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 The Authors. Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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