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Journal article

Impact of temporal variation on design and analysis of mouse knockout phenotyping studies

Abstract:

A significant challenge facing high-throughput phenotyping of in-vivo knockout mice is ensuring phenotype calls are robust and reliable. Central to this problem is selecting an appropriate statistical analysis that models both the experimental design (the workflow and the way control mice are selected for comparison with knockout animals) and the sources of variation. Recently we proposed a mixed model suitable for small batch-oriented studies, where controls are not phenotyped concurrently w...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
9
Issue:
10
Pages:
e111239
Publication date:
2014-10-24
Acceptance date:
2014-09-18
DOI:
EISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:a8da074a-6ebe-47a9-8f41-3692c717fbe2
Local pid:
pubs:488414
Source identifiers:
488414
Deposit date:
2014-11-08

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