T-cell activation through immunological synapses and kinapses.

Journal article

T-cell activation requires 'contact' with antigen-presenting cells (APCs) to bring the T-cell receptor (TCR) and antigenic major histocompatibility complex (MHC)-peptide complex together. Contact is defined by the size of the TCR and MHC-peptide complex, which at approximately 13 nm requires extensive interdigitation of the glycocalyx of the T cell and APC. T cells may be activated through formation of a stable T cell-APC junction, referred to as an immunological synapse. It has also been sho...

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Authors: Dustin, M

• Journal: Immunological reviews
• Volume: 221
• Issue: 1
• Pages: 77-89
• Publication date: 2008-02-01
• DOI: 10.1111/j.1600-065x.2008.00589.x
• EISSN: 1600-065X
• ISSN: 0105-2896
• Language: English
• Keywords: Cell Communication; Signal Transduction; Immunologic Capping; Animals; Antigen-Presenting Cells; Lymphocyte Activation; T-Lymphocytes; Gap Junctions