Journal article icon

Journal article

T-cell activation through immunological synapses and kinapses.

Abstract:

T-cell activation requires 'contact' with antigen-presenting cells (APCs) to bring the T-cell receptor (TCR) and antigenic major histocompatibility complex (MHC)-peptide complex together. Contact is defined by the size of the TCR and MHC-peptide complex, which at approximately 13 nm requires extensive interdigitation of the glycocalyx of the T cell and APC. T cells may be activated through formation of a stable T cell-APC junction, referred to as an immunological synapse. It has also been sho...

Expand abstract

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Immunological reviews More from this journal
Volume:
221
Issue:
1
Pages:
77-89
Publication date:
2008-02-01
DOI:
EISSN:
1600-065X
ISSN:
0105-2896
Language:
English
Keywords:
Pubs id:
pubs:426320
UUID:
uuid:a8d43405-686f-4427-a90c-e688ab2668d7
Local pid:
pubs:426320
Source identifiers:
426320
Deposit date:
2014-07-10

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP