Journal article icon

Journal article

Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer.

Abstract:

Histone modifications are key regulators of chromatin function. However, little is known to what extent histone modifications can directly impact on chromatin. Here, we address how a modification within the globular domain of histones regulates chromatin function. We demonstrate that H3K122ac can be sufficient to stimulate transcription and that mutation of H3K122 impairs transcriptional activation, which we attribute to a direct effect of H3K122ac on histone-DNA binding. In line with this, w...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.cell.2013.01.032

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Cell More from this journal
Volume:
152
Issue:
4
Pages:
859-872
Publication date:
2013-02-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Language:
English
Keywords:
Pubs id:
pubs:387976
UUID:
uuid:a8cc4055-eee1-45ae-b267-6aa1384e84e9
Local pid:
pubs:387976
Source identifiers:
387976
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP