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A comparison of oral artesunate and artemether antimalarial bioactivities in acute falciparum malaria.

Abstract:

AIMS: Artesunate and artemether are the two most widely used artemisinin derivatives in the treatment of uncomplicated Plasmodium falciparum malaria, but there is little information on their comparative pharmacokinetics. The aim of this study was to examine the relative oral antimalarial bioavailability and pharmacokinetics of the two derivatives. METHODS: The pharmacokinetic properties of oral artesunate and artemether (4 mg kg(-1)) were compared in a randomized cross-over study of 14 adult...

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Publication status:
Published

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Authors


Suputtamongkol, Y More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Teja-Isavadharm, P More by this author
Keeratithakul, D More by this author
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Journal:
British journal of clinical pharmacology
Volume:
52
Issue:
6
Pages:
655-661
Publication date:
2001-12-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:a87a2b33-bd0c-471a-9fe8-c26e8c981b19
Source identifiers:
26664
Local pid:
pubs:26664

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