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Journal article

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.

Abstract:

Co-receptors add complexity to cell-cell signaling systems. The secreted semaphorin 3s (Sema3s) require a co-receptor, neuropilin (Nrp), to signal through plexin As (PlxnAs) in functions ranging from axon guidance to bone homeostasis, but the role of the co-receptor is obscure. Here we present the low-resolution crystal structure of a mouse semaphorin-plexin-Nrp complex alongside unliganded component structures. Dimeric semaphorin, two copies of plexin and two copies of Nrp are arranged as a ...

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Publication status:
Published

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Publisher copy:
10.1038/nsmb.2416

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
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Journal:
Nature structural and molecular biology
Volume:
19
Issue:
12
Pages:
1293-1299
Publication date:
2012-12-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Source identifiers:
357913
Language:
English
Keywords:
Pubs id:
pubs:357913
UUID:
uuid:a86916d8-143f-4a02-9e0a-72b9444f1e56
Local pid:
pubs:357913
Deposit date:
2013-11-16

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