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Journal article

Structural basis of the 9-fold symmetry of centrioles.

Abstract:

The centriole, and the related basal body, is an ancient organelle characterized by a universal 9-fold radial symmetry and is critical for generating cilia, flagella, and centrosomes. The mechanisms directing centriole formation are incompletely understood and represent a fundamental open question in biology. Here, we demonstrate that the centriolar protein SAS-6 forms rod-shaped homodimers that interact through their N-terminal domains to form oligomers. We establish that such oligomerizatio...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2011.01.008

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Cell More from this journal
Volume:
144
Issue:
3
Pages:
364-375
Publication date:
2011-02-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Language:
English
Keywords:
Pubs id:
pubs:196807
UUID:
uuid:a82a45d9-16ad-402b-ba1e-a7a89371c7a1
Local pid:
pubs:196807
Source identifiers:
196807
Deposit date:
2012-12-19

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