Journal article icon

Journal article

Genotype imputation for genome-wide association studies.

Abstract:

In the past few years genome-wide association (GWA) studies have uncovered a large number of convincingly replicated associations for many complex human diseases. Genotype imputation has been used widely in the analysis of GWA studies to boost power, fine-map associations and facilitate the combination of results across studies using meta-analysis. This Review describes the details of several different statistical methods for imputing genotypes, illustrates and discusses the factors that infl...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/nrg2796

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics, Clinical Medicine
Role:
Author
Journal:
Nature reviews. Genetics
Volume:
11
Issue:
7
Pages:
499-511
Publication date:
2010-07-05
DOI:
EISSN:
1471-0064
ISSN:
1471-0056
URN:
uuid:a8270466-4a88-4281-94f1-da7e42dcd197
Source identifiers:
97505
Local pid:
pubs:97505

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP