Journal article

Genotype imputation for genome-wide association studies.

Abstract:: In the past few years genome-wide association (GWA) studies have uncovered a large number of convincingly replicated associations for many complex human diseases. Genotype imputation has been used widely in the analysis of GWA studies to boost power, fine-map associations and facilitate the combination of results across studies using meta-analysis. This Review describes the details of several different statistical methods for imputing genotypes, illustrates and discusses the factors that influence imputation performance, and reviews methods that can be used to assess imputation performance and test association at imputed SNPs.

Publication status:: Published

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APA Style

Marchini, J., & Howie, B. (2010). Genotype imputation for genome-wide association studies. Nature Reviews. Genetics, 11(7), 499–511.

MLA Style

Marchini, J, and B Howie. “Genotype Imputation for Genome-Wide Association Studies.” Nature Reviews. Genetics, vol. 11, no. 7, 2010, pp. 499–511.

Chicago Style

Marchini, J, and B Howie. 2010. “Genotype Imputation for Genome-Wide Association Studies.” Nature Reviews. Genetics 11 (7): 499–511.
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Publisher copy:: 10.1038/nrg2796

Authors

+ Marchini, J More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Role:: Author

+ Howie, B More by this author

Role:: Author

Journal:: Nature reviews. Genetics More from this journal
Volume:: 11
Issue:: 7
Pages:: 499-511
Publication date:: 2010-07-01
DOI:: 10.1038/nrg2796
EISSN:: 1471-0064
ISSN:: 1471-0056

Language:: English
Keywords:: Polymorphism, Single Nucleotide

Models, Genetic

Genome-Wide Association Study

Biostatistics

Genotype
Pubs id:: pubs:97505
UUID:: uuid:a8270466-4a88-4281-94f1-da7e42dcd197
Local pid:: pubs:97505
Source identifiers:: 97505
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_a82704664a88428194f1da7e42dcd197

Terms of use

Copyright date:: 2010

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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