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HIV maintains an evolving and dispersed population among multiple tissues during suppressive cART with periods of rapid expansion corresponding to the onset of cancer.

Abstract:

While combined antiretroviral therapy (cART) can result in undetectable plasma viral loads, it does not eradicate HIV infection. Furthermore, HIV-infected individuals while on cART remain at an increased risk of developing serious co-morbidities, such as cancer, neurological disease, and atherosclerosis, suggesting that during cART, tissue-based HIV may contribute to such pathologies.


We obtained DNA and RNA env, nef and pol sequences using single genome sequencing ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/JVI.00684-16

Authors


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Name:
National Institute of Neurological Disorders and Stroke
Grant:
NS063897
More from this funder
Name:
National Cancer Institute
Grant:
UM1 CA181255
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Name:
National Institute of Mental Health
Grant:
NIMH U24MH100929
Publisher:
American Society for Microbiology
Journal:
Journal of Virology More from this journal
Volume:
90
Issue:
20
Pages:
8984-8993
Publication date:
2016-07-01
Acceptance date:
2016-07-13
DOI:
ISSN:
1098-5514 and 0022-538X
Pmid:
27466425
Language:
English
Keywords:
Pubs id:
pubs:637509
UUID:
uuid:a8179eb5-4692-4591-96c5-bb72e756bd6e
Local pid:
pubs:637509
Source identifiers:
637509
Deposit date:
2016-11-07

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