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Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells

Abstract:

Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged receptors, a hallmark of adaptive lymphocytes. In some people infected with human cytomegalovirus (HCMV), an NK cell subset expressing the activating receptor NKG2C undergoes clonal-like expansion that partially resembles anti-viral adaptive responses. However, the viral ligand that drives the activation and differentiation of adaptive NKG2C+ NK cells has remained unclear. Here we found that adaptive NKG2C+...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41590-018-0082-6

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Role:
Author
ORCID:
0000-0003-2968-6061
Publisher:
Springer Nature
Journal:
Nature Immunology More from this journal
Volume:
19
Issue:
5
Pages:
453-463
Place of publication:
United States
Publication date:
2018-04-09
Acceptance date:
2018-02-26
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Pmid:
29632329
Language:
English
Keywords:
Pubs id:
1024170
Local pid:
pubs:1024170
Deposit date:
2020-03-12

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