Genetically indistinguishable SNPs and their influence on inferring the location of disease-associated variants.

Journal article

As part of a recent high-density linkage disequilibrium (LD) study of chromosome 20, we obtained genotypes for approximately 30,000 SNPs at a density of 1 SNP/2 kb on four different population samples (47 CEPH founders; 91 UK unrelateds [unrelated white individuals of western European ancestry]; 97 African Americans; 42 East Asians). We observed that approximately 50% of SNPs had at least one genetically indistinguishable partner; i.e., for every individual considered, their genotype at the f...

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Authors: Lawrence, R; Evans, D; Morris, A; Ke, X; Hunt, S

• Publication status: Published
• Journal: Genome research
• Volume: 15
• Issue: 11
• Pages: 1503-1510
• Publication date: 2005-11-01
• DOI: 10.1101/gr.4217605
• EISSN: 1549-5469
• ISSN: 1088-9051
• Language: English
• Keywords: Sample Size; Chromosomes, Human, Pair 20; Asian Continental Ancestry Group; Genetic Testing; Genomics; Polymorphism, Single Nucleotide; African Americans; Humans; Genotype; Great Britain; Linkage Disequilibrium; Computer Simulation; Gene Components; European Continental Ancestry Group; Chromosome Mapping; Evolution, Molecular