Journal article icon

Journal article

Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin 1

Abstract:

Ring-shaped cohesin keeps sister chromatids paired until cleavage of its Scc1/Rad21 subunit by separase triggers chromosome segregation in anaphase. Vertebrate separase is held inactive by mutually exclusive binding to securin or Cdk1-cyclin B1 and becomes unleashed only upon ubiquitin-dependent degradation of these regulators. Although most separase is usually found in association with securin, this anaphase inhibitor is dispensable for murine life while Cdk1-cyclin B1-dependent control of s...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Funding agency for:
Novak, B
Grant:
MitoSys/241548
Publisher:
Elsevier Publisher's website
Journal:
Molecular Cell Journal website
Volume:
58
Issue:
3
Pages:
495-506
Publication date:
2015-04-01
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Pubs id:
pubs:524445
UUID:
uuid:a804d473-b6cf-4bf6-b693-6d15951e9f3c
Local pid:
pubs:524445
Source identifiers:
524445
Deposit date:
2015-07-08

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP