Journal article
Fatigue predicts quality of life after leucine-rich glioma-inactivated 1-antibody encephalitis
- Abstract:
- Patient-reported quality-of-life (QoL) and carer impacts are not reported after leucine-rich glioma-inactivated 1-antibody encephalitis (LGI1-Ab-E). From 60 patients, 85% (51 out of 60) showed one abnormal score across QoL assessments and 11 multimodal validated questionnaires. Compared to the premorbid state, QoL significantly deteriorated (p < 0.001) and, at a median of 41 months, fatigue was its most important predictor (p = 0.025). In total, 51% (26 out of 51) of carers reported significant burden. An abbreviated five-item battery explained most variance in QoL. Wide-ranging impacts post-LGI1-Ab-E include decreased QoL and high caregiver strain. We identify a rapid method to capture QoL in routine clinic or clinical trial settings.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 486.9KB, Terms of use)
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- Publisher copy:
- 10.1002/acn3.52006
Authors
- Publisher:
- Wiley
- Journal:
- Annals of Clinical and Translational Neurology More from this journal
- Volume:
- 11
- Issue:
- 4
- Pages:
- 1053-1058
- Publication date:
- 2024-02-01
- Acceptance date:
- 2024-01-15
- DOI:
- EISSN:
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2328-9503
- ISSN:
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2328-9503
- Pmid:
-
38303486
- Language:
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English
- Keywords:
- Pubs id:
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1611638
- Local pid:
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pubs:1611638
- Deposit date:
-
2024-04-07
Terms of use
- Copyright holder:
- Binks et al.
- Copyright date:
- 2024
- Rights statement:
- © 2024 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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