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Death commitment point is advanced by axotomy in sympathetic neurons.

Abstract:

Axotomized neurons have several characteristics that are different from intact neurons. Here we show that, unlike established cultures, the axotomized sympathetic neurons deprived of NGF become committed to die before caspase activation, since the same proportion of NGF-deprived neurons are rescued by NGF regardless of whether caspases are inhibited by the pan-caspase inhibitor Boc-Asp(O-methyl)-CH(2)F (BAF). Despite prolonged Akt and ERK signaling induced by NGF after BAF treatment has preve...

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Publisher copy:
10.1083/jcb.150.4.741

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
The Journal of cell biology
Volume:
150
Issue:
4
Pages:
741-754
Publication date:
2000-08-05
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:a7daec9c-a4d1-4b9b-a404-76dac8617a83
Source identifiers:
111442
Local pid:
pubs:111442

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