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Death commitment point is advanced by axotomy in sympathetic neurons.

Abstract:

Axotomized neurons have several characteristics that are different from intact neurons. Here we show that, unlike established cultures, the axotomized sympathetic neurons deprived of NGF become committed to die before caspase activation, since the same proportion of NGF-deprived neurons are rescued by NGF regardless of whether caspases are inhibited by the pan-caspase inhibitor Boc-Asp(O-methyl)-CH(2)F (BAF). Despite prolonged Akt and ERK signaling induced by NGF after BAF treatment has preve...

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Publisher copy:
10.1083/jcb.150.4.741

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Journal of cell biology
Volume:
150
Issue:
4
Pages:
741-754
Publication date:
2000-08-01
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Source identifiers:
111442

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