Journal article
Death commitment point is advanced by axotomy in sympathetic neurons.
- Abstract:
-
Axotomized neurons have several characteristics that are different from intact neurons. Here we show that, unlike established cultures, the axotomized sympathetic neurons deprived of NGF become committed to die before caspase activation, since the same proportion of NGF-deprived neurons are rescued by NGF regardless of whether caspases are inhibited by the pan-caspase inhibitor Boc-Asp(O-methyl)-CH(2)F (BAF). Despite prolonged Akt and ERK signaling induced by NGF after BAF treatment has preve...
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- Publisher copy:
- 10.1083/jcb.150.4.741
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Authors
Bibliographic Details
- Journal:
- Journal of cell biology
- Volume:
- 150
- Issue:
- 4
- Pages:
- 741-754
- Publication date:
- 2000-08-01
- DOI:
- EISSN:
-
1540-8140
- ISSN:
-
0021-9525
- Source identifiers:
-
111442
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:111442
- UUID:
-
uuid:a7daec9c-a4d1-4b9b-a404-76dac8617a83
- Local pid:
- pubs:111442
- Deposit date:
- 2013-02-20
Terms of use
- Copyright date:
- 2000
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