- Abstract:
-
Axotomized neurons have several characteristics that are different from intact neurons. Here we show that, unlike established cultures, the axotomized sympathetic neurons deprived of NGF become committed to die before caspase activation, since the same proportion of NGF-deprived neurons are rescued by NGF regardless of whether caspases are inhibited by the pan-caspase inhibitor Boc-Asp(O-methyl)-CH(2)F (BAF). Despite prolonged Akt and ERK signaling induced by NGF after BAF treatment has preve...
Expand abstract - Publisher copy:
- 10.1083/jcb.150.4.741
-
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- Journal:
- The Journal of cell biology
- Volume:
- 150
- Issue:
- 4
- Pages:
- 741-754
- Publication date:
- 2000-08-05
- DOI:
- EISSN:
-
1540-8140
- ISSN:
-
0021-9525
- URN:
-
uuid:a7daec9c-a4d1-4b9b-a404-76dac8617a83
- Source identifiers:
-
111442
- Local pid:
- pubs:111442
- Language:
- English
- Keywords:
- Copyright date:
- 2000
Journal article
Death commitment point is advanced by axotomy in sympathetic neurons.
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