Axotomized neurons have several characteristics that are different from intact neurons. Here we show that, unlike established cultures, the axotomized sympathetic neurons deprived of NGF become committed to die before caspase activation, since the same proportion of NGF-deprived neurons are rescued by NGF regardless of whether caspases are inhibited by the pan-caspase inhibitor Boc-Asp(O-methyl)-CH(2)F (BAF). Despite prolonged Akt and ERK signaling induced by NGF after BAF treatment has preve...Expand abstract
- Publisher copy:
- Copyright date:
Death commitment point is advanced by axotomy in sympathetic neurons.
If you are the owner of this record, you can report an update to it here: Report update to this record