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Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues

Abstract:

Voltage-dependent K⁺ channels transfer the voltage sensor movement into gate opening or closure through an electromechanical coupling. To test functionally whether an interaction between the S4-S5 linker (L45) and the cytoplasmic end of S6 (S6T) constitutes this coupling, the L45 in hKv1.5 was replaced by corresponding hKv2.1 sequence. This exchange was not tolerated but could be rescued by also swapping (S6T). Exchanging both L45 and (S6T) residue substitutio...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1085/jgp.200810048

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Institution:
University of Antwerp, Belgium
Department:
Laboratory for Molecular Biophysics,Physiology,and Pharmacology,Department of Biomedical Sciences
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Institution:
University of Antwerp, Belgium
Department:
Laboratory for Molecular Biophysics,Physiology,and Pharmacology,Department of Biomedical Sciences
More by this author
Institution:
Consorzio Interuniversitario per le Applicazioni del Supercalcolo per Universita e Ricerca (CASPUR), Rome, Italy
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Institution:
University of Antwerp, Belgium
Department:
Laboratory for Molecular Biophysics,Physiology,and Pharmacology,Department of Biomedical Sciences
More by this author
Institution:
University of Oxford
Research group:
Laboratory for Molecular Biophysics
Department:
Medical Sciences Division - Biochemistry
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Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of General Physiology Journal website
Volume:
132
Issue:
6
Pages:
667-680
Publication date:
2008-12-05
DOI:
EISSN:
1540-7748
ISSN:
0022-1295
URN:
uuid:a7d4fc31-3f94-40d9-b77f-84a277958edb
Local pid:
ora:3407

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