Evidence that increased 5-HT release evokes region-specific effects on blood-oxygenation level-dependent functional magnetic resonance imaging responses in the rat brain.

Journal article

This study aimed to determine the potential of in vivo functional magnetic resonance imaging (fMRI) methods as a non-invasive means of detecting effects of increased 5-HT release in brain. Changes in blood-oxygenation level-dependent (BOLD) contrast induced by administration of the 5-HT-releasing agent, fenfluramine, were measured in selected brain regions of halothane-anesthetized rats. Initial immunohistochemical measurements of the marker of neural activation, Fos, confirmed that in haloth...

Expand abstract

Authors: Preece, M; Taylor, M; Raley, J; Blamire, A; Sharp, T

• Publication status: Published
• Journal: Neuroscience
• Volume: 159
• Issue: 2
• Pages: 751-759
• Publication date: 2009-03-01
• DOI: 10.1016/j.neuroscience.2008.12.032
• EISSN: 1873-7544
• ISSN: 0306-4522
• Language: English
• Keywords: Fenfluramine; Serotonin Antagonists; Drug Interactions; Dose-Response Relationship, Drug; Animals; Excitatory Amino Acid Transporter 3; Fenclonine; Magnetic Resonance Imaging; Male; Oncogene Proteins v-fos; Time Factors; Oxygen; Image Processing, Computer-Assisted; Rats, Sprague-Dawley; Brain; Brain Mapping; Serotonin; Rats; Serotonin Uptake Inhibitors