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Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci

Abstract:

Genome-wide association studies (GWAS) have identified >500 common variants associated with quantitative metabolic traits, but in aggregate such variants explain at most 20-30% of the heritable component of population variation in these traits. To further investigate the impact of genotypic variation on metabolic traits, we conducted re-sequencing studies in >6,000 members of a Finnish population cohort (The Northern Finland Birth Cohort of 1966 [NFBC]) and a type 2 diabetes case-contro...

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Journal:
PLoS Genetics
Volume:
10
Issue:
1
Publication date:
2014-01-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:a7ba6727-91dc-4ba8-a3bb-bb29b674e898
Source identifiers:
459206
Local pid:
pubs:459206
Language:
English

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