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Mammalian base excision repair: the forgotten archangel.

Abstract:

Base excision repair (BER) is a frontline repair system that is responsible for maintaining genome integrity and thus preventing premature aging, cancer and many other human diseases by repairing thousands of DNA lesions and strand breaks continuously caused by endogenous and exogenous mutagens. This fundamental and essential function of BER not only necessitates tight control of the continuous availability of basic components for fast and accurate repair, but also requires temporal and spati...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkt076

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Funding agency for:
Dianov, GL
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Funding agency for:
Dianov, GL
Swiss National Science Foundation More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
41
Issue:
6
Pages:
3483-3490
Publication date:
2013-04-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:a7b9aa9d-e409-4da9-87fe-671cbb31b182
Source identifiers:
384174
Local pid:
pubs:384174

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