Journal article icon

Journal article

Mammalian base excision repair: the forgotten archangel.

Abstract:

Base excision repair (BER) is a frontline repair system that is responsible for maintaining genome integrity and thus preventing premature aging, cancer and many other human diseases by repairing thousands of DNA lesions and strand breaks continuously caused by endogenous and exogenous mutagens. This fundamental and essential function of BER not only necessitates tight control of the continuous availability of basic components for fast and accurate repair, but also requires temporal and spati...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1093/nar/gkt076

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More from this funder
Name:
Medical Research Council
Funding agency for:
Dianov, G
More from this funder
Name:
Cancer Research UK
Funding agency for:
Dianov, G
More from this funder
Name:
Royal Society
Funding agency for:
Dianov, G
Publisher:
Oxford University Press
Journal:
Nucleic acids research More from this journal
Volume:
41
Issue:
6
Pages:
3483-3490
Publication date:
2013-04-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Language:
English
Keywords:
UUID:
uuid:a7b9aa9d-e409-4da9-87fe-671cbb31b182
Local pid:
pubs:384174
Source identifiers:
384174
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP