Journal article icon

Journal article

The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone.

Abstract:

Estrogen withdrawal in women leads initially to rapid bone loss caused by increased numbers or activity of osteoclasts. We previously have noted apoptosis of lacunar osteocytes associated with conditions of high bone turnover. Therefore, in this study, we investigated whether the increased bone loss associated with GnRH analogue (GnRH-a)-induced estrogen withdrawal affects osteocyte viability in situ in a way that would be directly contrary to the effect of estrogens on osteoclast viability. ...

Expand abstract

Actions


Access Document


Publisher copy:
10.1210/jcem.82.9.4200

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
J Clin Endocrinol Metab More from this journal
Volume:
82
Issue:
9
Pages:
3128-3135
Publication date:
1997-09-01
DOI:
ISSN:
0021-972X
Language:
English
Keywords:
Pubs id:
pubs:484967
UUID:
uuid:a7b4880a-7586-4f33-9dfe-b9f36cc925db
Local pid:
pubs:484967
Source identifiers:
484967
Deposit date:
2014-09-23

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP