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Ovine male genital duct epithelial cells differentiate in vitro and express functional CFTR and ENaC.

Abstract:

To investigate the biology of the male genital duct epithelium, we have established cell cultures from the ovine vas deferens and epididymis epithelium. These cells develop tight junctions, high transepithelial electrical resistance, and a lumen-negative transepithelial potential difference as a sign of active transepithelial ion transport. In epididymis cultures the equivalent short-circuit current (I(sc)) averaged 20.8+/-0.7 microA/cm(2) (n = 150) and was partially inhibited by apical appli...

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Authors


Bielfeld-Ackermann, A More by this author
Bassett, J More by this author
Ferguson, DJ More by this author
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Journal:
American journal of physiology. Cell physiology
Volume:
278
Issue:
5
Pages:
C885-C894
Publication date:
2000-05-05
EISSN:
1522-1563
ISSN:
0363-6143
URN:
uuid:a7b031da-a464-4ad6-8a47-cbf6a5828bf9
Source identifiers:
247667
Local pid:
pubs:247667

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