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DNA damage consistent with apoptosis in transient focal ischaemic neocortex.

Abstract:

Transient focal ischaemia was produced in rat right neocortex by temporary middle cerebral artery occlusion. DNA damage was visualized in situ in cells of this right hemisphere but not in the contralateral hemisphere. The extracted damaged DNA exhibited laddered fragmentation which is indicative of apoptotic degradation. The amount of DNA damage was quantified by an end-labelling technique and shown to increase with the duration of the ischaemic insult. We conclude that the neurodegeneration ...

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Publication status:
Published

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Journal:
Neuroreport More from this journal
Volume:
5
Issue:
4
Pages:
493-496
Publication date:
1994-01-01
DOI:
EISSN:
1473-558X
ISSN:
0959-4965
Language:
English
Keywords:
Pubs id:
pubs:80184
UUID:
uuid:a7a121d7-abad-4823-aa98-4bbbdaaeeed3
Local pid:
pubs:80184
Source identifiers:
80184
Deposit date:
2012-12-19

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