Journal article
Refining molecular analysis in the pathways of colorectal carcinogenesis.
- Abstract:
-
BACKGROUND and AIMS: In the stepwise model, specific genetic and epigenetic changes accumulate as colorectal adenomas progress to carcinomas (CRCs). CRCs also acquire global phenotypes, particularly microsatellite instability (MSI) and aneuploidy/polyploidy (chromosomal instability, CIN). Few changes specific to MSI-low or CIN+ cancers have been established. METHODS: We investigated 100 CRCs for: mutations and loss of heterozygosity (LOH) where appropriate, of APC, K-ras, BRAF, SMAD4, and p5...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/s1542-3565(05)00618-x
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Bibliographic Details
- Journal:
- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
- Volume:
- 3
- Issue:
- 11
- Pages:
- 1115-1123
- Publication date:
- 2005-11-01
- DOI:
- EISSN:
-
1542-7714
- ISSN:
-
1542-3565
- Source identifiers:
-
72044
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:72044
- UUID:
-
uuid:a777bba9-5c25-4a90-9aa3-3d03c843c97a
- Local pid:
- pubs:72044
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2005
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