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Journal article

Refining molecular analysis in the pathways of colorectal carcinogenesis.

Abstract:

BACKGROUND and AIMS: In the stepwise model, specific genetic and epigenetic changes accumulate as colorectal adenomas progress to carcinomas (CRCs). CRCs also acquire global phenotypes, particularly microsatellite instability (MSI) and aneuploidy/polyploidy (chromosomal instability, CIN). Few changes specific to MSI-low or CIN+ cancers have been established. METHODS: We investigated 100 CRCs for: mutations and loss of heterozygosity (LOH) where appropriate, of APC, K-ras, BRAF, SMAD4, and p5...

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Publication status:
Published

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Journal:
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Volume:
3
Issue:
11
Pages:
1115-1123
Publication date:
2005-11-01
DOI:
EISSN:
1542-7714
ISSN:
1542-3565
Source identifiers:
72044
Language:
English
Keywords:
Pubs id:
pubs:72044
UUID:
uuid:a777bba9-5c25-4a90-9aa3-3d03c843c97a
Local pid:
pubs:72044
Deposit date:
2012-12-19

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