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A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA.

Abstract:

The mechanism by which p38 mitogen-activated protein kinase (MAPK) regulates the induction of cyclooxygenase (COX)-2 by interleukin-1 (IL-1) has been investigated in HeLa cells. SB 203580, an inhibitor of p38 MAPK, in the range 0.1-1 microM inhibited IL-1-stimulated PGE2 (but not arachidonic acid) release and this was associated with inhibition of induction of COX-2 protein and mRNA. IL-1 stimulated COX-2 transcription in HeLa cells about 2-fold as judged by both reporter gene and nuclear run...

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Authors


Ridley, SH More by this author
Sarsfield, SJ More by this author
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Journal:
FEBS letters
Volume:
439
Issue:
1-2
Pages:
75-80
Publication date:
1998-11-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:a776b07e-eca3-4093-b663-33cabb49cf09
Source identifiers:
430185
Local pid:
pubs:430185

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