Preprint
OrthoFinder: scalable phylogenetic orthology inference for comparative genomics
- Abstract:
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Here, we present a major advance of the OrthoFinder method. This extends OrthoFinder’s high accuracy comparative genomic framework to provide substantially enhanced scalability and accuracy. Specifically, we show that enhanced phylogenetic delineation of orthogroups provides a 7% relative increase in orthogroup inference accuracy. We further demonstrate that a new gene assignment method substantially reduces overall runtime RAM usage without compromising accuracy. The latest version of OrthoFinder is available at https://github.com/OrthoFinder/OrthoFinder.
- Publication status:
- Published
- Peer review status:
- Not peer reviewed
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- Files:
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(Preview, Pre-print, pdf, 626.5KB, Terms of use)
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- Preprint server copy:
- 10.1101/2025.07.15.664860
Authors
+ Wellcome Trust
More from this funder
- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 226598/Z/22/Z
- Preprint server:
- bioRxiv
- Publication date:
- 2025-07-16
- DOI:
- Server owner:
- Cold Spring Harbor Laboratory
- Language:
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English
- Pubs id:
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2247319
- Local pid:
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pubs:2247319
- Deposit date:
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2026-06-03
- ARK identifier:
Terms of use
- Copyright holder:
- Emms et al.
- Copyright date:
- 2025
- Rights statement:
- The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
- Licence:
- CC Attribution (CC BY)
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