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Journal article

Prion-like spreading of Alzheimer's disease within the brain's connectome

Abstract:

The prion hypothesis states that misfolded proteins can act as infectious agents that template the misfolding and aggregation of healthy proteins to transmit a disease. Increasing evidence suggests that pathological proteins in neurodegenerative diseases adopt prion-like mechanisms and spread across the brain along anatomically connected networks. Local kinetic models of protein misfolding and global network models of protein spreading provide valuable insight into several aspects of prion-li...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Oxford college:
St Catherine's College
Role:
Author
ORCID:
0000-0002-6436-8483
Publisher:
Royal Society
Journal:
Interface More from this journal
Volume:
16
Issue:
159
Article number:
20190356
Publication date:
2019-10-16
Acceptance date:
2019-09-23
EISSN:
1742-5662
ISSN:
1742-5689
Keywords:
Pubs id:
pubs:991195
UUID:
uuid:a7533fff-71b4-4fc8-a086-db71b68fb9b0
Local pid:
pubs:991195
Source identifiers:
991195
Deposit date:
2019-10-10

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