A Peptide to Reduce Pulmonary Edema in a Rat Model of Lung Transplantation

Journal article

T cells from recipient rats retrieved 28 days post LTX were mixed with irradiated spleen cells from donors and showed a significant reduction in proliferation as compared to control-treated animals (A, mean +/- SD, p = 0,000; n = 6). (B) The peptide did not directly alter lymphocyte proliferation: PBMCs were incubated with XIB13 or control peptide for 3 days (mean +/- SD, p = 0,178; n = 3); (C) The effect was not due to increased exposure of recipients to donor cells as measured by numbers of donor DNA copies in the recipients blood (B, mean +/- SD, p = 0,360; n = 6). XIB13 had no effect on Wet/Dry-ratios, cell influx and cytokine secretion in ventilation-induced lung injury in mice not subjected to any surgical procedure (Fig 4).

Authors: Schossleitner, K; Habertheuer, A; Finsterwalder, R; Friedl, HP; Rauscher, S

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Public Library of Science
• Journal: PLoS ONE
• Volume: 10
• Issue: 11
• Pages: e0142115-e0142115
• Publication date: 2015-11-04
• DOI: 10.1371/journal.pone.0142115
• EISSN: 1932-6203
• ISSN: 1932-6203
• Language: English
• Keywords: Transplantation; Lung; Edema; Anesthesia; Perioperative; Medicine; Internal medicine; Surgery; Pulmonary edema; Lung transplantation; Oxygenation