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The human subthalamic nucleus encodes the subjective value of reward and the cost of effort during decision-making

Abstract:

Adaptive behaviour entails the capacity to select actions as a function of their energy cost and expected value and the disruption of this faculty is now viewed as a possible cause of the symptoms of Parkinson's disease. Indirect evidence points to the involvement of the subthalamic nucleus-the most common target for deep brain stimulation in Parkinson's disease-in cost-benefit computation. However, this putative function appears at odds with the current view that the subthalamic nucleus is ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1093/brain/aww075

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Publisher:
Oxford University Press (OUP) Publisher's website
Journal:
Brain Journal website
Volume:
139
Issue:
6
Pages:
1830–1843
Publication date:
2016-04-28
Acceptance date:
2016-02-24
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:a7449086-413d-4070-81b0-f60144817af1
Source identifiers:
623195
Local pid:
pubs:623195

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