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Comparative analysis of the CDR loops of antigen receptors

Abstract:

The adaptive immune system uses two main types of antigen receptors: T-cell receptors (TCRs) and antibodies. While both proteins share a globally similar β-sandwich architecture, TCRs are specialised to recognise peptide antigens in the binding groove of the major histocompatibility complex, while antibodies can bind an almost infinite range of molecules. For both proteins, the main determinants of target recognition are the complementarity-determining region (CDR) loops. Five of the six CDRs...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2019.02454

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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Oxford college:
New College
Role:
Author
ORCID:
0000-0003-4029-6902
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Statistics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Statistics
Role:
Author
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Name:
Engineering and Physical Sciences Research Council
Grant:
EP/L016044/1
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
10
Article number:
2454
Publication date:
2019-10-15
Acceptance date:
2019-10-01
DOI:
EISSN:
1664-3224
Keywords:
Pubs id:
pubs:1059265
UUID:
uuid:a72cf7ff-85f2-4048-8fa9-80d77c970ddf
Local pid:
pubs:1059265
Source identifiers:
1059265
Deposit date:
2019-10-02

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