The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis.

Journal article

Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the disease. We have previously demonstrated suggestive linkage of AS to chromosome 2q13, a region containing the interleukin 1 (IL-1) family gene cluster, which includes several strong candidates for involvement in the disease. In the current study,...

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Authors: Timms, A; Crane, A; Sims, A; Cordell, H; Bradbury, L

• Publication status: Published
• Journal: American journal of human genetics
• Volume: 75
• Issue: 4
• Pages: 587-595
• Publication date: 2004-10-01
• DOI: 10.1086/424695
• EISSN: 1537-6605
• ISSN: 0002-9297
• Language: English
• Keywords: HLA-B27 Antigen; Interleukin-1; Great Britain; Haplotypes; Inheritance Patterns; Genotype; Chromosomes, Human, Pair 2; Polymorphism, Single Nucleotide; DNA Primers; Humans; Genetic Predisposition to Disease; Gene Frequency; Spondylitis, Ankylosing; Electrophoresis, Agar Gel; DNA Mutational Analysis