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The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis.

Abstract:

Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the disease. We have previously demonstrated suggestive linkage of AS to chromosome 2q13, a region containing the interleukin 1 (IL-1) family gene cluster, which includes several strong candidates for involvement in the disease. In the current study,...

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Publication status:
Published

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Publisher copy:
10.1086/424695

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Journal:
American journal of human genetics More from this journal
Volume:
75
Issue:
4
Pages:
587-595
Publication date:
2004-10-01
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Language:
English
Keywords:
Pubs id:
pubs:108695
UUID:
uuid:a71e3292-a8ee-4fea-93b2-6360586be3be
Local pid:
pubs:108695
Source identifiers:
108695
Deposit date:
2012-12-19

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