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Journal article

The harmonic mean p-value for combining dependent tests

Abstract:

Analysis of “big data” frequently involves statistical comparison of millions of competing hypotheses to discover hidden processes underlying observed patterns of data, for example, in the search for genetic determinants of disease in genome-wide association studies (GWAS). Controlling the familywise error rate (FWER) is considered the strongest protection against false positives but makes it difficult to reach the multiple testing-corrected significance threshold. Here, I introduce the harmo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1814092116

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-0940-3311
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
116
Issue:
4
Pages:
1195-1200
Publication date:
2019-01-22
Acceptance date:
2018-12-04
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
30610179
Language:
English
Keywords:
Pubs id:
pubs:957873
UUID:
uuid:a714e0ba-6ca6-4032-b089-761ade025c3f
Local pid:
pubs:957873
Source identifiers:
957873
Deposit date:
2019-01-24

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